C57BL/6 Mice

C57BL/6 mice are the most used inbred strain in research. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. Inbred mouse strains exhibit a high degree of uniformity in their inherited characteristics, or phenotypes, which include appearance, behavior, and response to experimental treatments. We couple our International Genetic Standardization (IGS) program with a pyramid mating system designed to maintain the highest levels of genetic uniformity in our C57BL/6 mice. The pyramid mating system ensures that our C57BL/6 mice are genetically identical within each mouse strain. Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To The Jackson Laboratory in 1948 from Hall. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH.