C57BL/6 Mice

C57BL/6 mice (Black 6 mice) are among the most widely used inbred mouse strains in biomedical research. Their well-characterized genetic background and high degree of phenotypic uniformity make them useful for studies where reproducibility and consistency are critical, including immunology, safety and efficacy testing, transgenic and knockout model development, and diet-induced obesity research.Charles River maintains C57BL/6NCrl colonies through our International Genetic Standardization (IGS) program and pyramid mating system, which are designed to preserve genetic uniformity and reduce variability that could affect research results.We also offer the C57BL/6-Aged Mouse, the C57BL/6 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in the US), and the C57BL/6 SOPF Mouse with a SOPF health profile (bred in France). Through our preconditioning services, we can also provide DIO (diet-induced obesity) C57BL/6 mice.OriginDeveloped by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To The Jackson Laboratory in 1948 from Hall. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH.