BALB/c Mice

The BALB/c mouse is among the most widely used inbred models used in biomedical research, and is particularly utilized in immunology and infectious disease research. Their ability to produce plasma cell tumors within soft tissue is important in the production of monoclonal antibodies (mAbs). With BALB/c mice, Th2 cells are easily triggered by immunization, meaning this mouse strain is an exceptional responder to immunization. The BALB/c model can be used to identify genes that determine susceptibility to infectious and neoplastic diseases. BALB/c mice is also known for being relatively resistant to diet-induced atherosclerosis, making them ideal for cardiovascular research. BALB/c 3T3 cell lines are highly disposed to transformation in tissue culture by the oncogenic DNA virus SV40 and murine sarcoma virus, making them a model of choice for carcinogenesis research. Origin H.J. Bagg developed the “Bagg albino” in 1913 from stock from an Ohio pet dealer. Inbred in 1923 by McDowell. To Snell in 1932 at F26, then to Andervont in 1935. To NIH in 1951 from Andervont at F72. To Charles River in 1974 from NIH.