NCI SCID/NCr Mouse

SCID mice possess a genetic autosomal recessive mutation Prkdcscid. Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal natural killer (NK) cells, macrophages and granulocytes. NCI received this mouse in 1991. To Charles River in 2014. Note: See our isolator page for available immunocompromised animal housing units.