OT II Mouse

From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.​Guidebook to Rodent Model Genetic Quality ControlLearn the essentials of genetic QC programs: inbred/outbred colony quality control, transgenic rodent model creation, rederivation, and cryopreservation techniques.Download NowFind additional knockout models through our collaboration with genOway