NSG-MHC DKO I/II Mice

NSG-MHC I/II DKO mutant mice combine the features of the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency, MHC class I molecule deficiency (H2-K and D), and MHC class II molecule deficiency (IA) and exhibit a significant delay in the onset of graft-versus-host disease (GvHD). They provide a model useful to study in vivo mechanisms of xenogeneic GvHD and to rapidly assess therapeutic agents.Note: Use of mice by for-profit entities requires a JAX Leap License prior to shipping. For more information, please see Terms of Use. This includes mice shipped as part of our Animal Model Evaluation Program. Purchase of mice by for-profit entities are subject to commercial pricing. Please contact your local Charles River office for further information or assistance.OriginThe breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX® mice stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory's breeding protocols and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to those bred by The Jackson Laboratory and are considered authentic JAX® Mice strains which are designated with a 'J' as the final letter in the strain nomenclature. JAX® mice strains are for internal research use only and should not be propagated for distribution or sale.Strain CharacteristicsFor comprehensive strain information, see the strain data sheet.Research ApplicationsOncology, immunology, xenograft/transplant host, humanized mouse studies (outstanding utility in the study of graft-versus-host disease. These mice exhibit a significantly delayed onset of xenogeneic GvHD compared to NSG® mice).